【药物名称】Iprocolol, P-16
化学结构式(Chemical Structure):
参考文献No.900424
标题:
作者:
来源:FR 2077694
合成路线图解说明:

The oxidation of khelline (I) with nitric acid gives khellinequinone (II), which is reduced with SO2 yielding khellinequinol (III). The condensation of (III) with epichlorohydrin (IV) affords the 2,3-epoxypropyl ether of khellinequinol (V) (1), which is condensed with benzylisopropylamine (VI) by heating at 110 C giving 3-benzylisopropylamino-2-hydroxypropyl ether of khellinequinol (VII). Finally this compound is debenzylated by reduction with H2 over Pd/C in methanol - acetic acid (1,2). Compound (V) can also be obtained by direct reaction of khellinequinol (III) with 3-(benzylisopropvlamino)-2-hydroxy-1-chloropropane (VIII) by means of NaH in refluxing ethanol (1,2).

参考文献No.950182
标题:Synthesis and B-adrenolytic properties of some amino alcohol derivatives of furo [3,2-g]chromone
作者:Martin, M.; et al.
来源:Eur J Med Chem - Chim Ther 1974,9(5),563-570
合成路线图解说明:

The oxidation of khelline (I) with nitric acid gives khellinequinone (II), which is reduced with SO2 yielding khellinequinol (III). The condensation of (III) with epichlorohydrin (IV) affords the 2,3-epoxypropyl ether of khellinequinol (V) (1), which is condensed with benzylisopropylamine (VI) by heating at 110 C giving 3-benzylisopropylamino-2-hydroxypropyl ether of khellinequinol (VII). Finally this compound is debenzylated by reduction with H2 over Pd/C in methanol - acetic acid (1,2). Compound (V) can also be obtained by direct reaction of khellinequinol (III) with 3-(benzylisopropvlamino)-2-hydroxy-1-chloropropane (VIII) by means of NaH in refluxing ethanol (1,2).

参考文献No.950183
标题:Iprocrolol
作者:Casta馿r, J.; Weetman, D.F.
来源:Drugs Fut 1978,3(11),816
合成路线图解说明:

The oxidation of khelline (I) with nitric acid gives khellinequinone (II), which is reduced with SO2 yielding khellinequinol (III). The condensation of (III) with epichlorohydrin (IV) affords the 2,3-epoxypropyl ether of khellinequinol (V) (1), which is condensed with benzylisopropylamine (VI) by heating at 110 C giving 3-benzylisopropylamino-2-hydroxypropyl ether of khellinequinol (VII). Finally this compound is debenzylated by reduction with H2 over Pd/C in methanol - acetic acid (1,2). Compound (V) can also be obtained by direct reaction of khellinequinol (III) with 3-(benzylisopropvlamino)-2-hydroxy-1-chloropropane (VIII) by means of NaH in refluxing ethanol (1,2).

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