【药物名称】Butocrolol, P-18
化学结构式(Chemical Structure):
参考文献No.900400
标题:
作者:
来源:FR 2232311
合成路线图解说明:

The demethylation-oxidation of khelline (I) with HNO3 gives khellinequinone (II), which is reduced with SO2 to khellinequinol (III). The reaction of (III) with epichlorohydrine by means of triethylamine yields the 2,3-epoxypropyl ether (IV), which is treated with benzyl tert-butylamine at 120 C to afford the tertiary amine (V). Finally this compound is debenzylated by hydrogenation with H2 over Pd/C in methanol - acetic acid.

参考文献No.950159
标题:Synthesis and B-adrenolytic properties of some amino alcohol derivatives of furo [3,2-g]chromone
作者:Martin, M.; et al.
来源:Eur J Med Chem - Chim Ther 1974,9(5),563-570
合成路线图解说明:

The demethylation-oxidation of khelline (I) with HNO3 gives khellinequinone (II), which is reduced with SO2 to khellinequinol (III). The reaction of (III) with epichlorohydrine by means of triethylamine yields the 2,3-epoxypropyl ether (IV), which is treated with benzyl tert-butylamine at 120 C to afford the tertiary amine (V). Finally this compound is debenzylated by hydrogenation with H2 over Pd/C in methanol - acetic acid.

参考文献No.950160
标题:Butocrolol
作者:Casta馿r, J.; Weetman, D.F.
来源:Drugs Fut 1978,3(8),569
合成路线图解说明:

The demethylation-oxidation of khelline (I) with HNO3 gives khellinequinone (II), which is reduced with SO2 to khellinequinol (III). The reaction of (III) with epichlorohydrine by means of triethylamine yields the 2,3-epoxypropyl ether (IV), which is treated with benzyl tert-butylamine at 120 C to afford the tertiary amine (V). Finally this compound is debenzylated by hydrogenation with H2 over Pd/C in methanol - acetic acid.

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