Trebenzomine, CI-686(hydrochloride)-药物合成数据库

【药物名称】Trebenzomine, CI-686(hydrochloride)

化学结构式(Chemical Structure):

参考文献No.	900399
标题:
作者:	Lockhart, J.M.
来源:	DE 1919560; FR 2007481; GB 1151474; ZA 6902723

合成路线图解说明: The reduction of 2-methyl-3-nitro-2H-1-benzopyran (I) with LiAlH4 in ether gives 2-methyl-3-chromanamine (II), which is then methylated by refluxing with a mixture of formaldehyde and formic acid, or by reaction with formaldehyde and hydrogen over Pd/C in water.

参考文献No.	950158
标题:	Trebenzomine
作者:	Casta馿r, J.; Owen, R.T.
来源:	Drugs Fut 1978,3(7),556

合成路线图解说明: The reduction of 2-methyl-3-nitro-2H-1-benzopyran (I) with LiAlH4 in ether gives 2-methyl-3-chromanamine (II), which is then methylated by refluxing with a mixture of formaldehyde and formic acid, or by reaction with formaldehyde and hydrogen over Pd/C in water.