The cyclization of glycerol (I) with 2,4-dichlorophenacyl bromide (II) by means of p-toluenesulfonic acid in a refluxing mixture of toluene and butanol gives 2-bromomethyl-2-(2,4-dichlorophenyl)-4-(hydroxymethyl)-1,3-dioxolane (III), which by esterification with benzoyl chloride (IV) in pyridine followed by a fractionated crystallization affords cis-2-bromomethyl-2-(2,4-dichlorophenyl)-4-(benzoyloxymehyl)-3-dioxolane (V). The hydrolysis of (V) with NaOH in refluxing dioxane - water yields the corresponding alcohol (VI), which by reaction with imidazole (VII) by means of KI in refluxing dimethylacetamide gives cis-2-(1H-imidazol-1-ylmethyl)-2-(2,4-dichlorophenyl)-4-(hydroxymethyl)-1,3-dioxolane (VIII). Finally this compound is condensed with 3-chloro-1-propyn (IX) by means of NaH in DMF.

The cyclization of glycerol (I) with 2,4-dichlorophenacyl bromide (II) by means of p-toluenesulfonic acid in a refluxing mixture of toluene and butanol gives 2-bromomethyl-2-(2,4-dichlorophenyl)-4-(hydroxymethyl)-1,3-dioxolane (III), which by esterification with benzoyl chloride (IV) in pyridine followed by a fractionated crystallization affords cis-2-bromomethyl-2-(2,4-dichlorophenyl)-4-(benzoyloxymehyl)-3-dioxolane (V). The hydrolysis of (V) with NaOH in refluxing dioxane - water yields the corresponding alcohol (VI), which by reaction with imidazole (VII) by means of KI in refluxing dimethylacetamide gives cis-2-(1H-imidazol-1-ylmethyl)-2-(2,4-dichlorophenyl)-4-(hydroxymethyl)-1,3-dioxolane (VIII). Finally this compound is condensed with 3-chloro-1-propyn (IX) by means of NaH in DMF.