【药物名称】Orconazole nitrate, R-15556
化学结构式(Chemical Structure):
参考文献No.803978
标题:The preparation and properties of derivatives of 1-phenethyl imidazole
作者:Godefroi, E.F.; et al.
来源:J Med Chem 1969,12(5),784
合成路线图解说明:

Reaction of p-chlorophenacyl bromide (I) with imidazole (II) affords 4'-chloro-2-(1-imidazolyl)acetophenone (III). Sodium borohydride reduction gives the corresponding alcohol (IV) which is then alkylated with 2,6-dichlorobenzyl chloride (V) to give orconazole (VI). Treatment of (VI) with nitric acid yield the title compound

参考文献No.803979
标题:Orconazole nitrate
作者:Arya, V.P.
来源:Drugs Fut 1979,4(6),432
合成路线图解说明:

Reaction of p-chlorophenacyl bromide (I) with imidazole (II) affords 4'-chloro-2-(1-imidazolyl)acetophenone (III). Sodium borohydride reduction gives the corresponding alcohol (IV) which is then alkylated with 2,6-dichlorobenzyl chloride (V) to give orconazole (VI). Treatment of (VI) with nitric acid yield the title compound

参考文献No.900212
标题:
作者:Godefroi, E.F.; Heeres, J. (Janssen Pharmaceutica NV)
来源:BE 737575; DE 1940388; FR 2015913; GB 1244530; JP 76115; US 3717655; US 3839574; ZA 6905965
合成路线图解说明:

Reaction of p-chlorophenacyl bromide (I) with imidazole (II) affords 4'-chloro-2-(1-imidazolyl)acetophenone (III). Sodium borohydride reduction gives the corresponding alcohol (IV) which is then alkylated with 2,6-dichlorobenzyl chloride (V) to give orconazole (VI). Treatment of (VI) with nitric acid yield the title compound

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