Terbufibrol can be obtained in two different ways: 1) Condensation of 4-tert-butylphenol (I) with epichlorohydrin (II) by means of NaOH in methanol gives 1,2-epoxy-3-(4'-tert-butylphenoxy)propane (III) which is condensed with methyl 4-hydroxybenzoate (IV) in the presence of a catalytic amount of a base yielding the methyl ester (V) which is then hydrolyzed with NaOH and finally acidified to yield terbufibrol. 2) Condensation of methyl 4-hydroxybenzoate (IV) with epichlorohydrin (II) by means of NaOH in methanol gives 1,2-epoxy-3-(4'-methoxycarbonylphenoxy)propane (VI) which is condensed with 4-tert-butylphenol (I) in the presence of a catalytic amount of a base yielding the methyl ester (V) which is then hydrolyzed with NaOH and finally acidified to yield terbufibrol.

Terbufibrol can be obtained in two different ways: 1) Condensation of 4-tert-butylphenol (I) with epichlorohydrin (II) by means of NaOH in methanol gives 1,2-epoxy-3-(4'-tert-butylphenoxy)propane (III) which is condensed with methyl 4-hydroxybenzoate (IV) in the presence of a catalytic amount of a base yielding the methyl ester (V) which is then hydrolyzed with NaOH and finally acidified to yield terbufibrol. 2) Condensation of methyl 4-hydroxybenzoate (IV) with epichlorohydrin (II) by means of NaOH in methanol gives 1,2-epoxy-3-(4'-methoxycarbonylphenoxy)propane (VI) which is condensed with 4-tert-butylphenol (I) in the presence of a catalytic amount of a base yielding the methyl ester (V) which is then hydrolyzed with NaOH and finally acidified to yield terbufibrol.