【药物名称】Nicafenine
化学结构式(Chemical Structure):
参考文献No.900341
标题:
作者:Cousse, H.; Mouzin, G.
来源:BE 849004; CH 608804; DE 2656852; FR 2335223; NL 7613605; US 4122181; US 4152521
合成路线图解说明:

The esterification of 2-carboxyphenylcarbamic acid anhydride (I) with N-(2-hydroxyethyl)nicotinamide (II) by means of NaOH in hot dioxane gives the corresponding ester of anthranilic acid (III), which is then condensed with 4,7-dichloroquinoline (IV) in refluxing ethanol.

参考文献No.950088
标题:Nicafenine
作者:Aboul-Enein, H.Y.
来源:Drugs Fut 1980,5(7),357
合成路线图解说明:

The esterification of 2-carboxyphenylcarbamic acid anhydride (I) with N-(2-hydroxyethyl)nicotinamide (II) by means of NaOH in hot dioxane gives the corresponding ester of anthranilic acid (III), which is then condensed with 4,7-dichloroquinoline (IV) in refluxing ethanol.

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