UCL-1608-药物合成数据库

【药物名称】UCL-1608

化学结构式(Chemical Structure):

参考文献No.	633491
标题:	Synthesis and structure-activity relationships of cetiedil analogues as blockers of the Ca2+-activated K+ permeability of erythrocytes
作者:	Roxburgh, C.J.; Ganellin, C.R.; Athmani, S.; Bisi, A.; Quaglia, W.; Benton, D.C.; Shiner, M.A.; Malik-Hall, M.; Haylett, D.G.; Jenkinson, D.H.
来源:	J Med Chem 2001,44(20),3244

合成路线图解说明: The cuprous chloride-catalyzed Mannich reaction between propargyl alcohol (I), hexahydroazepine (II) and formaldehyde furnished aminobutynol (III), which was further converted to the corresponding chloride (IV) upon treatment with SOCl2. The title compound was then synthesized by alkylation of the anion of 9-benzylfluorene (V) with chloride (IV) in DMSO.