【药物名称】
化学结构式(Chemical Structure):
参考文献No.630325
标题:Synthesis of salicylihalamide A and B analogs and their in vitro cytotoxicity
作者:Blais, C.; et al.
来源:222nd ACS Natl Meet (Aug 26 2001, Chicago) 2001,Abst MEDI 94
合成路线图解说明:

The previously reported alcohol (I) was used as the starting material for the synthesis of the title compound. Alcohol (I) was oxidized to aldehyde (II) using N-methylmorpholine-N-oxide in the presence of a catalytic amount of tetrapropylammonium perruthenate. The phenolic hydroxyl group of (II) was subsequently protected as the silyl ether (III) by treatment with triisopropylsilyl chloride. The symmetrical N,N-bis-acylated aminal (V) was synthesized by condensation of aldehyde (III) with amide (IV) in the presence of trimethylsilyl triflate. Elimination of one amide moiety of (V) with NaH in refluxing toluene produced a mixture of (E)- and (Z)-enamides, from which the desired (E)-isomer (VI) could be separated by flash chromatography either at this point or after the next step. Finally, desilylation with tetrabutylammonium fluoride in THF furnished the deprotected compound.

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