【药物名称】Etiprednol dicloacetate, BNP-166, Respicort, Ethinase, Cronaze
化学结构式(Chemical Structure):
参考文献No.56567
标题:Androstene derivs.
作者:Bodor, N.S. (Soft Drugs, Inc.)
来源:WO 9742214
合成路线图解说明:

The oxidative cleavage of prednisolone (I) using sodium metaperiodate produces carboxylic acid (II). Regioselective esterification of diol (II) with dichloroacetyl chloride (III) under phase-transfer conditions gives the 17-ester (IV). The title ethyl ester is then obtained by esterification of (IV) with iodoethane in the presence of NaHCO3 and tetrabutylammonium hydrogensulfate.

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