-药物合成数据库

【药物名称】

化学结构式(Chemical Structure):

参考文献No.	50604
标题:	Substd. benzofuranoindoles and indenoindoles as novel potassium channel openers
作者:	Butera, J.A.; Antane, S.A.; Lennox, J.R. (Wyeth)
来源:	EP 1135393; US 6288099; WO 0034285

合成路线图解说明: The condensation between 5-chloro-3(2H)benzofuranone (I) and 2-hydrazinobenzoic acid (II) afforded the corresponding hydrazone (III). This was subjected to microwave-promoted Fischer indole cyclization in formic acid to produce the target benzofuroindole tetracyclic system.

参考文献No.	629159
标题:	Synthesis and potassium channel opening activity of substituted 10H-benzo[4,5]furo[3,2-b]indole- and 5,10-dihydro-indeno[1,2-b]indole-1-carboxylic acids
作者:	Butera, J.A.; Antane, S.A.; Hirth, B.H.; Lennox, J.R.; Sheldon, J.H.; Norton, N.W.; Warga, D.; Argentieri, T.M.
来源:	Bioorg Med Chem Lett 2001,11(16),2093

合成路线图解说明: The condensation between 5-chloro-3(2H)benzofuranone (I) and 2-hydrazinobenzoic acid (II) afforded the corresponding hydrazone (III). This was subjected to microwave-promoted Fischer indole cyclization in formic acid to produce the target benzofuroindole tetracyclic system.