-药物合成数据库

【药物名称】

化学结构式(Chemical Structure):

参考文献No.	38249
标题:	Amino acid derivs.
作者:	Seko, T.; Kato, M. (Ono Pharmaceutical Co., Ltd.)
来源:	EP 0997147; WO 9902146

合成路线图解说明: Alkylation of L-cysteine (I) with cyclopentylmethyl methanesulfonate (II) produced the cysteine thioether (III). A tert-butoxycarbonyl group was subsequently introduced into the amino group of (III) by using di-tert-butyl dicarbonate and NaOH. The resultant N-Boc-cysteine thioether (V) was finally coupled with p-methoxybenzylamine (VI) by means of EDC and HOBt to furnish the corresponding amide.

参考文献No.	629162
标题:	Structure-activity study and analgesic efficacy of amino acid derivatives as N-type calcium channel blockers
作者:	Seko, T.; Kato, M.; Kohno, H.; Ono, S.; Hashimura, K.; Takimizu, H.; Nakai, K.; Maegawa, H.; Katsube, N.; Toda, M.
来源:	Bioorg Med Chem Lett 2001,11(16),2067

合成路线图解说明: Alkylation of L-cysteine (I) with cyclopentylmethyl methanesulfonate (II) produced the cysteine thioether (III). A tert-butoxycarbonyl group was subsequently introduced into the amino group of (III) by using di-tert-butyl dicarbonate and NaOH. The resultant N-Boc-cysteine thioether (V) was finally coupled with p-methoxybenzylamine (VI) by means of EDC and HOBt to furnish the corresponding amide.