【药物名称】BN-81674
化学结构式(Chemical Structure):
参考文献No.627516
标题:Identification of potent non-peptide somatostatin antagonists with sst3 selectivity
作者:Poitout, L.; Roubert, P.; Contour-Galcera, M.O.; Moinet, C.; Lannoy, J.; Pommier, J.; Plas, P.; Bigg, D.; Thurieau, C.
来源:J Med Chem 2001,44(18),2990
合成路线图解说明:

Phenacyl ester (III) was prepared by treatment of the cesium salt of N-Boc-tryptophan (I) with 2-bromoacetophenone (II) in DMF. Cyclization of keto ester (III) with ammonium acetate in refluxing xylene yielded the target imidazole (IV). Acidic Boc group deprotection of (IV) then gave amine (V). Finally, Pictet-Spengler cyclization of (V) with 6-undecanone (VI) provided the desired tetrahydrocarboline.

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