【药物名称】ORG-25969
化学结构式(Chemical Structure):
参考文献No.49625
标题:6-Mercapto-cyclodextrin derivs.: Reversal agents for drug-induced neuromuscular block
作者:Bennet, D.J.; Palin, R.; Zhang, M. (Akzo Nobel N.V.)
来源:WO 0140316
合成路线图解说明:

Gamma-cyclodextrin (I) was converted to the halogen derivative (II) by treatment with iodine or bromine and triphenylphosphine. Nucleophilic displacement of the halogen atoms of (II) with the sodium salt of 3-mercaptopropionic acid furnished the title compound

参考文献No.664983
标题:Cyclodextrin-derived host molecules as reversal agents for the neuromuscular blocker rocuronium bromide: Synthesis and structure-activity relationships
作者:Adam, J.M.; Bennet, D.J.; Bom, A.; Clark, J.K.; Feilden, H.; Hutchinson, E.J.; Palin, R.; Prosser, A.; Rees, D.C.; Rosair, G.M.; Stevenson, D.; Tarver, G.J.; Zhang, M.Q.
来源:J Med Chem 2002,45(9),1806
合成路线图解说明:

Gamma-cyclodextrin (I) was converted to the halogen derivative (II) by treatment with iodine or bromine and triphenylphosphine. Nucleophilic displacement of the halogen atoms of (II) with the sodium salt of 3-mercaptopropionic acid furnished the title compound

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