Triclabendazole, CGA-89317, Fasinex-药物合成数据库

【药物名称】Triclabendazole, CGA-89317, Fasinex

化学结构式(Chemical Structure):

参考文献No.	804000
标题:	Triclabendazole
作者:	Serradell, M.N.; Casta馿r, J.; Thorpe, P.J.
来源:	Drugs Fut 1984,9(8),593

合成路线图解说明: The cyclization of 4-chloro-5-(2,3-dichlorophenoxy)-o-phenylenediamine (I) with carbon disulfide gives 5-chloro-6-(2,3-dichlorophenoxy)-2H-1,3-dihydrobenzimidazole-2-thione (II), which is methylated with methyl iodide and KOH in ethanol - water

参考文献No.	900229
标题:
作者:	Gallay, J.J.; Kuehne, M.E.; Meyer, A.; Rechsteiner, O.; Schellenbaum, M. (Ciba Geigy A.-G.)
来源:	DE 2815621; FR 2387220; US 4197307

合成路线图解说明: The cyclization of 4-chloro-5-(2,3-dichlorophenoxy)-o-phenylenediamine (I) with carbon disulfide gives 5-chloro-6-(2,3-dichlorophenoxy)-2H-1,3-dihydrobenzimidazole-2-thione (II), which is methylated with methyl iodide and KOH in ethanol - water