【药物名称】Moxaprindine
化学结构式(Chemical Structure):
参考文献No.803996
标题:Moxaprindine
作者:Blancafort, P.; Serradell, M.N.; Casta馿r, J.; Thorpe, P.J..
来源:Drugs Fut 1981,6(6),354
合成路线图解说明:

This compound can be prepared by three different related ways: 1) By condensation of 1-methoxy-2-aminoindane (I) with 3-bromopropyl diethylamine (II) by means of sodium amide in refluxing toluene (1). 2) The reaction of (I) with 1-chloro-3-bromopropane (III) by heating at 100 C gives the corresponding N-(3-chloropropyl) derivative (IV), which is then condensed with diethylamine by means of NaI in refluxing ethanol (2). 3) By condensation of 1-methoxy-2-indanyl methanesulfonate (V) with N-(diethylaminopropyl)aniline (VI) in refluxing ethanol (2).

参考文献No.900225
标题:
作者:Vanhoof, P.; De Ridder, R. (A. Christiaens SA)
来源:CA 1068239; CH 617663; DD 123598; ZA 7607468
合成路线图解说明:

This compound can be prepared by three different related ways: 1) By condensation of 1-methoxy-2-aminoindane (I) with 3-bromopropyl diethylamine (II) by means of sodium amide in refluxing toluene (1). 2) The reaction of (I) with 1-chloro-3-bromopropane (III) by heating at 100 C gives the corresponding N-(3-chloropropyl) derivative (IV), which is then condensed with diethylamine by means of NaI in refluxing ethanol (2). 3) By condensation of 1-methoxy-2-indanyl methanesulfonate (V) with N-(diethylaminopropyl)aniline (VI) in refluxing ethanol (2).

参考文献No.900226
标题:
作者:(A. Christiaens SA)
来源:
合成路线图解说明:

This compound can be prepared by three different related ways: 1) By condensation of 1-methoxy-2-aminoindane (I) with 3-bromopropyl diethylamine (II) by means of sodium amide in refluxing toluene (1). 2) The reaction of (I) with 1-chloro-3-bromopropane (III) by heating at 100 C gives the corresponding N-(3-chloropropyl) derivative (IV), which is then condensed with diethylamine by means of NaI in refluxing ethanol (2). 3) By condensation of 1-methoxy-2-indanyl methanesulfonate (V) with N-(diethylaminopropyl)aniline (VI) in refluxing ethanol (2).

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