Ipexidine mesylate, CK-0569(free base)-药物合成数据库

【药物名称】Ipexidine mesylate, CK-0569(free base)

化学结构式(Chemical Structure):

参考文献No.	900320
标题:
作者:	Wohl, R.A.
来源:	ZA 706373

合成路线图解说明: The reaction of S-methyl isothiouronium iodide (I) with n-hexyl isocyanate (II) by means of triethylamine in acetone gives N-(methylthioiminocarbonyl)-N?n-hexylurea (III), which is then condensed with 1,4-bis(3-aminopropyl)piperazine (IV) in refluxing isopropanol and methanesulfonic acid.

参考文献No.	950066
标题:	Ipexidine Mesylate
作者:	Blancafort, P.; Serradell, M.N.; Casta馿r, J.; Leeson, P.A.; Mealy, N.E.
来源:	Drugs Fut 1981,6(6),350

合成路线图解说明: The reaction of S-methyl isothiouronium iodide (I) with n-hexyl isocyanate (II) by means of triethylamine in acetone gives N-(methylthioiminocarbonyl)-N?n-hexylurea (III), which is then condensed with 1,4-bis(3-aminopropyl)piperazine (IV) in refluxing isopropanol and methanesulfonic acid.