【药物名称】Azastene, Win-17625
化学结构式(Chemical Structure):
参考文献No.900313
标题:
作者:Clinton, R.O.; Manson, A.J.
来源:US 3135743
合成路线图解说明:

The reaction of 4,4,17-trimethyl-17beta-hydroxy-5-androsten-3-one (I) with ethyl formate by means of sodium methoxide in benzene gives 4,4,17-trimethyl-17beta-hydroxy-2-hydroxymethylene-5-androsten-3-one (II), which is then cyclized with hydroxylamine hydrochloride by means of sodium acetate in refluxing acetic acid.

参考文献No.950058
标题:Azastene
作者:Blancafort, P.; Serradell, M.N.; Casta馿r, J.; Sungurbey, K.; Hillier, K.
来源:Drugs Fut 1982,7(12),859
合成路线图解说明:

The reaction of 4,4,17-trimethyl-17beta-hydroxy-5-androsten-3-one (I) with ethyl formate by means of sodium methoxide in benzene gives 4,4,17-trimethyl-17beta-hydroxy-2-hydroxymethylene-5-androsten-3-one (II), which is then cyclized with hydroxylamine hydrochloride by means of sodium acetate in refluxing acetic acid.

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