Tripropidil hydrochloride, MJ-12,880-1-药物合成数据库

【药物名称】Tripropidil hydrochloride, MJ-12,880-1

化学结构式(Chemical Structure):

参考文献No.	900300
标题:
作者:	Morrow, D.F.; Matier, W.L.
来源:	BE 871143; DE 2844353; FR 2405932; GB 2006197; JP 7988232; NL 7810156; ZA 7805689

合成路线图解说明: The diazotation of 4-aminophenol (I) with NaNO2 and HCl followed by reaction with isopropylmercaptane (II) gives 4-(isopropylthio)phenol (III), which is condensed with epichlorohydrin (IV) by means of NaOH in water to yield 3-[4-(isopropylthio)phenoxy]-1,2-epoxypropane (V). Finally this compound is condensed with n-octylamine (VI) in refluxing ethanol and treated with HCl.

参考文献No.	950047
标题:	Tipropidil Hydrochloride
作者:	Blancafort, P.; Serradell, M.N.; Casta馿r, J.; Thorpe, P.J.
来源:	Drugs Fut 1982,7(4),277

合成路线图解说明: The diazotation of 4-aminophenol (I) with NaNO2 and HCl followed by reaction with isopropylmercaptane (II) gives 4-(isopropylthio)phenol (III), which is condensed with epichlorohydrin (IV) by means of NaOH in water to yield 3-[4-(isopropylthio)phenoxy]-1,2-epoxypropane (V). Finally this compound is condensed with n-octylamine (VI) in refluxing ethanol and treated with HCl.