【药物名称】Oxaflozane
化学结构式(Chemical Structure):
参考文献No.900284
标题:
作者:
来源:DE 1910477; FR 1564792; GB 1221734; US 3637680
合成路线图解说明:

The reaction of 2-chloroethyl vinyl ether (III) with bromine gives 1,2-dibromo-2-[(2-chloro)ethoxy]ethane (IV) which reacts with the magnesian derivative (II) [obtained from (3-trifluoromethyl)bromobenzene (I) and magnesium in anhydrous ether] to give 2-[(3-trifluoromethyl)phenyl]-2-[(2-chloro)ethoxy]-1-bromoethane (V). The compound (V) is heated in an autoclave at 100 C with isopropylamine (VI) in toluene.

参考文献No.950024
标题:Tetrahydro-1,4-oxazines. I. Nex synthesis method and a study of their interaction with tryptaminergic D receptors
作者:Busch, N.; et al.
来源:Eur J Med Chem - Chim Ther 1976,11(3),201-7
合成路线图解说明:

The reaction of 2-chloroethyl vinyl ether (III) with bromine gives 1,2-dibromo-2-[(2-chloro)ethoxy]ethane (IV) which reacts with the magnesian derivative (II) [obtained from (3-trifluoromethyl)bromobenzene (I) and magnesium in anhydrous ether] to give 2-[(3-trifluoromethyl)phenyl]-2-[(2-chloro)ethoxy]-1-bromoethane (V). The compound (V) is heated in an autoclave at 100 C with isopropylamine (VI) in toluene.

参考文献No.950025
标题:Oxaflozane
作者:Serradell, M.N.; Blancafort, P.
来源:Drugs Fut 1978,3(9),667
合成路线图解说明:

The reaction of 2-chloroethyl vinyl ether (III) with bromine gives 1,2-dibromo-2-[(2-chloro)ethoxy]ethane (IV) which reacts with the magnesian derivative (II) [obtained from (3-trifluoromethyl)bromobenzene (I) and magnesium in anhydrous ether] to give 2-[(3-trifluoromethyl)phenyl]-2-[(2-chloro)ethoxy]-1-bromoethane (V). The compound (V) is heated in an autoclave at 100 C with isopropylamine (VI) in toluene.

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