【药物名称】Letosteine
化学结构式(Chemical Structure):
参考文献No.900273
标题:
作者:Chodkiewicz, M.X.
来源:BE 812653; DE 2410307; FR 2222087; GB 1452207; JP 74126666; JP 7741262; NL 7403785; US 4032534
合成路线图解说明:

The condensation of acrolein (I) with ethyl mercaptoacetate (II) by means of triethylamine in ether gives ethyl 3-oxopropylmercaptoacetate (III), which is then cyclized with cystein (IV) in ethanol - water.

参考文献No.950012
标题:Letosteine
作者:Blancafort, P.; Serradell, M.N.; Casta馿r, J.; Neuman, M.
来源:Drugs Fut 1979,4(10),729
合成路线图解说明:

The condensation of acrolein (I) with ethyl mercaptoacetate (II) by means of triethylamine in ether gives ethyl 3-oxopropylmercaptoacetate (III), which is then cyclized with cystein (IV) in ethanol - water.

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