【药物名称】
化学结构式(Chemical Structure):
参考文献No.50000
标题:Antimicrobial cpds.
作者:Dick, J.D.; Parrish, N.M.; Townsend, C.A.; Kuhajda, F.P.; Pasternack, G.R. (Johns Hopkins University)
来源:JP 2001514168; WO 9910321
合成路线图解说明:

Alkylation of methyl thioglycolate (I) with n-octyl bromide (II) gave the octyl thioether (III). The sulfide group was then oxidized to the sulfoxide (IV) by using either hydrogen peroxide in the presence of ammonium molybdate or m-chloroperbenzoic acid. The target amide was finally obtained by ammonolysis of the methyl ester function of (IV).

参考文献No.591197
标题:A new class of antituberculosis agents
作者:Jones, P.B.; Parrish, N.M.; Houston, T.A.; Stapon, A.; Bansal, N.P.; Dick, J,D.; Townsend, C.A.
来源:J Med Chem 2000,43(17),3304
合成路线图解说明:

Alkylation of methyl thioglycolate (I) with n-octyl bromide (II) gave the octyl thioether (III). The sulfide group was then oxidized to the sulfoxide (IV) by using either hydrogen peroxide in the presence of ammonium molybdate or m-chloroperbenzoic acid. The target amide was finally obtained by ammonolysis of the methyl ester function of (IV).

参考文献No.615015
标题:In vitro activity of a novel antimycobacterial compound, n-octanesulfonylacetamide, and its effects on lipid and mycolic acid synthesis
作者:Parrish, N.M.; Houston, T.A.; Jones, P.B.; Townsend, C.; Dick, J.D.
来源:Antimicrob Agents Chemother 2001,45(4),1143
合成路线图解说明:

Alkylation of methyl thioglycolate (I) with n-octyl bromide (II) gave the octyl thioether (III). The sulfide group was then oxidized to the sulfoxide (IV) by using either hydrogen peroxide in the presence of ammonium molybdate or m-chloroperbenzoic acid. The target amide was finally obtained by ammonolysis of the methyl ester function of (IV).

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