-药物合成数据库

【药物名称】

化学结构式(Chemical Structure):

参考文献No.	619222
标题:	Antiplasmodial activity and cytotoxicity of bis-, tris-, and tetraquinolines with linear or cyclic amino linkers
作者:	Girault, S.; Grellier, P.; Berceibar, A.; Maes, L.; Lemi鑢e, P.; Mouray, E.; Davioud-Charvet, E.; Sergheraert, C.
来源:	J Med Chem 2001,44(11),1658

合成路线图解说明: Condensation of 1,4,7-triazacyclononane (I) with 4,7-dichloroquinoline (II) produced the disubstituted derivative (III). Then, coupling of glutaric acid (IV) with amine (III) using bromo-tris-pyrrolidinophosphonium hexafluorophosphate gave the corresponding diamide.