【药物名称】NS-3623
化学结构式(Chemical Structure):
参考文献No.35192
标题:Phenyl derivs. containing an acidic group, their preparation and their use as chloridic channel blockers
作者:Christophersen, P.; Pedersen, O. (NeuroSearch A/S)
来源:EP 0906273; EP 0977741; JP 2000511167; WO 9745400; WO 9847879
合成路线图解说明:

The title urea derivative was obtained by condensation of 3-(trifluoromethyl)phenyl isocyanate (I) with anthranilic acid (II).

合成路线图解说明:

The target compound can be obtained by condensation of 3-trifluoromethylphenyl isocyanate (I) with 5-(2-amino-5-bromophenyl)tetrazole in toluene.

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