Cinacalcet hydrochloride, AMG-073, KRN-1493, AMG-073.HCl, Parareg, Mimpara, Sensipar-药物合成数据库

【药物名称】Cinacalcet hydrochloride, AMG-073, KRN-1493, AMG-073.HCl, Parareg, Mimpara, Sensipar

化学结构式(Chemical Structure):

参考文献No.	48464
标题:	Calcium receptor-active cpds.
作者:	Moe, S.T.; Balandrin, M.F.; Van Wagenen, B.C.; Nemeth, E.F.; DelMar, E.G. (NPS Pharmaceuticals, Inc.)
来源:	US 6211244

合成路线图解说明: Reaction of 1(R)-(1-naphthyl)ethylamine (I) with 3-[3-(trifluoromethyl)phenyl]propionaldehyde (II) by means of titanium tetraisopropoxide gives the corresponding imine (III), which is finally reduced with NaBH3CN in ethanol.

参考文献No.	695016
标题:	Cinacalcet Hydrochloride
作者:	Bay閟, M.; Casta馿r, R.M.; Sorbera, L.A.
来源:	Drugs Fut 2002,27(9),831

合成路线图解说明: Reaction of 1(R)-(1-naphthyl)ethylamine (I) with 3-[3-(trifluoromethyl)phenyl]propionaldehyde (II) by means of titanium tetraisopropoxide gives the corresponding imine (III), which is finally reduced with NaBH3CN in ethanol.