A-358-药物合成数据库

【药物名称】A-358

化学结构式(Chemical Structure):

参考文献No.	52806
标题:	Enzyme inhibitors
作者:	Madge, D.; Wishart, G.; Dolman, M.; Maunder, P. (Arrow Therapeutics Ltd.)
来源:	WO 0128537

合成路线图解说明: The acylation of 4-chlorobenzene-1,2-diamine (I) with 4-(trifluoromethoxy)benzenesulfonyl chloride (II) by means of pyridine in acetonitrile gives the target bis sulfonamide.

参考文献No.	645626
标题:	Synthesis and SAR of novel inhibitors of the shikimate pathway enzyme dehydroquinate synthase
作者:	Cockerill, S.; Chapman, S.; Chana, S.; et al.
来源:	41st Intersci Conf Antimicrob Agents Chemother (Dec 16 2001, Chicago) 2001,Abst F-1693

合成路线图解说明: The acylation of 4-chlorobenzene-1,2-diamine (I) with 4-(trifluoromethoxy)benzenesulfonyl chloride (II) by means of pyridine in acetonitrile gives the target bis sulfonamide.