【药物名称】(-)-2-(2-Bromohexadecanoyl)paclitaxel, BrC16HT, (-)-BRT-216
化学结构式(Chemical Structure):
参考文献No.48315
标题:Hydrolysis-promoting hydrophobic taxane derivs.
作者:Mayhew, E.; Janoff, A.S.; Bhattacharya, S.; Kehane, G.; Ahmad, I.; Franklin, J.C.; Ali, S. (The Liposome Company, Ltd.)
来源:US 6107332
合成路线图解说明:

Esterification of Taxol (paclitaxel) (I) with 2-bromohexadecanoic acid (II) by means of DCC in dichloromethane yields the target 2'-(2-bromohexadecanoyl)paclitaxel.

参考文献No.625471
标题:Hydrolyzable hydrophobic taxanes: Synthesis and anti-cancer activities
作者:Ali, S.; Ahmad, I.; Peters, A.; Masters, G.; Minchey, S.; Janoff, A.; Mayhew, E.
来源:Anti-Cancer Drugs 2001,12(2),117
合成路线图解说明:

The target compound is obtained by esterification of Taxol (paclitaxel) (I) with hexadecanoic anhydride (II) by means of DCC in dichloromethane.

合成路线图解说明:

Esterification of Taxol (paclitaxel) (I) with 2-bromohexadecanoic acid (II) by means of DCC in dichloromethane yields the target 2'-(2-bromohexadecanoyl)paclitaxel.

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