【药物名称】Isoxicam, W-9495, Maxicam
化学结构式(Chemical Structure):
参考文献No.47847
标题:4-Hydroxy-3-(3-isoxazolocarbamyl)-2H-1,2-benzothiazine-1-dioxides and process for their production
作者:Zinnes, H.; et al. (Pfizer Inc.)
来源:CA 978187; DE 2208351; FR 2128371; GB 1323283; US 3787324; US 3816628; US 3822258
合成路线图解说明:

By reaction of 3-carbethoxy-4-hydroxy-2-methyl-2H-1,2-benzothiazine-1,1-dioxide (I) with 3-amino-5-methylisoxazole (II) in refluxing xylene.

参考文献No.48061
标题:4-Acyloxy-3-(2-isoxazolocarbamyl)-2H-1,2-benzothiazine 1,1-dioxides
作者:Zinnes, H.; et al. (Pfizer Inc.)
来源:DE 2227742; FR 2143146; GB 1340289; US 3704298
合成路线图解说明:

By reaction of 3-carbethoxy-4-hydroxy-2-methyl-2H-1,2-benzothiazine-1,1-dioxide (I) with 3-amino-5-methylisoxazole (II) in refluxing xylene.

参考文献No.607660
标题:Antiinflammatory 3,4-dihydro-2-alkyl-3-oxo-2H-1,2-benzothiazine-4-carboxamide 1,1-dioxides
作者:Lombardino, J.G.; Wiseman, E.H.
来源:J Med Chem 1971,14(10),973
合成路线图解说明:

By reaction of 3-carbethoxy-4-hydroxy-2-methyl-2H-1,2-benzothiazine-1,1-dioxide (I) with 3-amino-5-methylisoxazole (II) in refluxing xylene.

参考文献No.612804
标题:Isoxicam
作者:Casta馿r, J.; Arrigoni-Martelli, E.
来源:Drugs Fut 1976,1(3),123
合成路线图解说明:

By reaction of 3-carbethoxy-4-hydroxy-2-methyl-2H-1,2-benzothiazine-1,1-dioxide (I) with 3-amino-5-methylisoxazole (II) in refluxing xylene.

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