-药物合成数据库

【药物名称】

化学结构式(Chemical Structure):

参考文献No.	610424
标题:	New 3-[4-(aryl)piperazin-1-yl]-1-(benzo[b]thiophen-3-yl)propane derivatives with dual action at 5-HT1A serotonin receptors and serotonin transporter as a new class of antidepressants
作者:	Mart韓ez, J.; Perez, S.; Oficialdegui, A.M.; Heras, B.; Orus, L.; Villanueva, H.; Palop, J.A.; Roca, J.; Mourelle, M.; Bosch, A.; Del Castillo, J.C.; Lasheras, B.; Tordera, R.; del Rio, J.; Monge, A.
来源:	Eur J Med Chem 2001,36(1),55

合成路线图解说明: Friedel-Crafts acylation of 5-fluorobenzothiophene (I) with 3-chloropropionyl chloride (II) in the presence of AlCl3 furnished the chloroketone (III). This was then condensed with N-(2-methoxyphenyl)piperazine (IV) to afford the piperazinyl ketone (V). Reduction of the keto group of (V) with NaBH4 then gave the title alcohol.