The reaction of 4-bromothiophene-3-carboxylic acid with SOCl2 gives the corresponding acyl chloride (II), which is condensed with N,O-dimethylhydroxylamine (III) to yield the amide (IV). The Grignard condensation of (IV) with 4-imidazolylmagnesium bromide (V) affords the methanone (VI), which is reduced with NaBH4 to the corresponding carbinol (VII). Finally, this alcohol is reduced and deprotected with BH3/Me2S in dichloromethane/THF.