-药物合成数据库

【药物名称】

化学结构式(Chemical Structure):

参考文献No.	608663
标题:	C-Isoprenylation of flavonoids enhances binding affinity toward P-glycoprotein and modulation of cancer cell chemoresistance
作者:	Comte, G.; Daskiewicz, J.-B.; Bayet, C.; Conseil, G.; Viornery-Vanier, A.; Dmontet, C.; Di Pietro, A.; Barron, D.
来源:	J Med Chem 2001,44(5),763

合成路线图解说明: In an improved procedure, chrysin (I) was alkylated with prenyl bromide (II) under phase-transfer conditions, and the resulting prenyl ether (III) was subsequently rearranged under microwave irradiation to produce a mixture of the title compound as the major product along with the 6-prenyl (VI) and the 6,8-diprenyl (VII) derivatives, which were separated by column chromatography.

参考文献No.	621104
标题:	Syntheses of 8-C-(1,1-dimethylallyl) flavones and 3-methyl flavonols
作者:	Mariotte, A.-M.; Barron, D.
来源:	Nat Prod Lett 1994,4(1),21

合成路线图解说明: Alkylation of chrysin (I) with prenyl bromide (II) in the presence of K2CO3 in acetone provided 7-O-(3,3-dimethylallyl)chrysin (III). Claisen rearrangement of (III) in the presence of NaOAc in refluxing Ac2O gave rise to the 8-(1,1-dimethylallyl) flavone (IV) and minor amounts of the desired 8-(3,3-dimethylallyl) analogue (V). Saponification of the mixture of acetate esters, followed by chromatographic separation, furnished the title 8-(3,3-dimethylallyl)chrysin.