【药物名称】CPT-154
化学结构式(Chemical Structure):
参考文献No.44941
标题:Camptothecin derivs. having antitumor activity
作者:Carminati, P.; Penco, S.; Zunino, F.; Merlini, L. (Istituto Nazionale per lo Studio e la Cura dei Tumori; Sigma-Tau Industrie Farmaceutiche Riunite SpA)
来源:EP 1044977; WO 0053607
合成路线图解说明:

Radical hydroxymethylation of camptothecin (I) by means of MeOH in the presence of H2O2 and FeSO4 provided (II). Subsequent heating of alcohol (II) in acetic acid gave rise to 7-formylcamptothecine (III). Finally, condensation of aldehyde (III) with O-t-butylhydroxylamine afforded the corresponding oxime.

合成路线图解说明:

The title imine derivative was prepared by condensation of the known 7-formylcamptothecin (I) with aniline (II) in the presence of ytterbium triflate and molecular sieves in CH2Cl2.

参考文献No.607952
标题:Novel cytotoxic 7-iminomethyl and 7-aminomethyl derivatives of camptothecin
作者:Dallavalle, S.; Ferrari, A.; Merlini, L.; Penco, S.; Carenini, N.; De Cesare, M.; Perego, P.; Pratesi, G.; Zunino, F.
来源:Bioorg Med Chem Lett 2001,11(3),291
合成路线图解说明:

The title imine derivative was prepared by condensation of the known 7-formylcamptothecin (I) with aniline (II) in the presence of ytterbium triflate and molecular sieves in CH2Cl2.

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