【药物名称】Dimethylaminoarglabin hydrochloride, Arglabin-DMA.HCl
化学结构式(Chemical Structure):
参考文献No.40311
标题:Pharmaceutical compsns. of arglabin and arglabin derivs.
作者:Adekenov, S.M. (Paracure, Inc.)
来源:US 5902809; WO 9848789
合成路线图解说明:

Arglabin (I) was isolated from the extracts of Artemisia glabella and was purified by column chromatography followed by crystallization from hexane. Conjugate addition of dimethylamine to the methylene lactone system of (I) provided the target dimethylamino derivative, which was finally converted to the corresponding hydrochloride salt.

参考文献No.47435
标题:Farnesyl-protein transferase inhibitors
作者:Shaikenov, T.E. (International Phytochemistry Research Laboratory Ltd.)
来源:WO 9943314
合成路线图解说明:

Arglabin (I) was isolated from the extracts of Artemisia glabella and was purified by column chromatography followed by crystallization from hexane. Conjugate addition of dimethylamine to the methylene lactone system of (I) provided the target dimethylamino derivative, which was finally converted to the corresponding hydrochloride salt.

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