【药物名称】CFM-1571
化学结构式(Chemical Structure):
参考文献No.43449
标题:Activators of soluble guanylate cyclase
作者:Glen, R.; Liu, Q.; Powell, K.; Reynolds, K.; Madge, D.; Kling, M.; Selwood, D.; Wishart, G. (University College London)
来源:WO 0027394
合成路线图解说明:

Condensation of 1-benzyl-3-hydroxy-1H-pyrazole-5-carboxylic acid methyl ester (I) with 3-(dimethylamino)-1-propanol (II) by means of 1,1'-(azodicarbonyl)dipiperidine and tributylphosphine under Mitsunobu conditions afforded the dimethylaminopropyl ether (III). After basic hydrolysis of the methyl ester group of (III), the resultant carboxylic acid (IV) was coupled with 4-methoxyaniline (V) using HATU to furnish the title amide.

参考文献No.603969
标题:Synthesis and biological evaluation of novel pyrazoles and indazoles as activators of the nitric oxide receptor, soluble guanylate cyclase
作者:Selwood, D.L.; Brummel, D.G.; Budworth, J.; Burtin, G.E.; Campbell, R.O.; Chana, S.S.; Charles, I.G.; Fernandez, P.A.; Glen, R.C.; Goggin, M.C.; Hobbs, A.J.; Kling, M.R.; Liu, Q.; Madge, D.J.; Meillerais, S.; Powell, K.L.; Reynolds, K.; et al.
来源:J Med Chem 2001,44(1),78
合成路线图解说明:

Condensation of 1-benzyl-3-hydroxy-1H-pyrazole-5-carboxylic acid methyl ester (I) with 3-(dimethylamino)-1-propanol (II) by means of 1,1'-(azodicarbonyl)dipiperidine and tributylphosphine under Mitsunobu conditions afforded the dimethylaminopropyl ether (III). After basic hydrolysis of the methyl ester group of (III), the resultant carboxylic acid (IV) was coupled with 4-methoxyaniline (V) using HATU to furnish the title amide.

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