【药物名称】SCH-442416
化学结构式(Chemical Structure):
参考文献No.596219
标题:Design, radiosynthesis, and biodistribution of a new potent and selective ligand for in vivo imaging of the adenosine A2A receptor system using positron emission tomography
作者:Todde, S.; Moresco, R.M.; Simonelli, P.; Baraldi, P.G.; Cacciari, B.; Spalluto, G.; Varani, K.; Monopoli, A.; Matarrese, M.; Carpinelli, A.; Magni, F.; Kienle, M.G.; Fazio, F.
来源:J Med Chem 2000,43(23),4359
合成路线图解说明:

The condensation between 3-(4-methoxyphenyl)propyl hydrazine (I) and (ethoxymethylene)malononitrile (II) afforded the pyrazole (III), which was transformed to the corresponding imidate (IV) by refluxing in triethyl orthoformate. Reaction of imidate (IV) with 2-furoic acid hydrazide (V) provided the pyrazolopyrimidine intermediate (VI), which was thermally cyclized in diphenyl ether to the tricyclic derivative (VII). Hydrolysis of (VII) with HCl induced the pyrimidine ring opening to furnish (VIII). This was finally converted into the title compound by treatment with cyanamide in N-methylpyrrolidone.

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