DAPT, LY-374973, AN-37124-药物合成数据库

【药物名称】DAPT, LY-374973, AN-37124

化学结构式(Chemical Structure):

参考文献No.	45635
标题:	Methods and cpds. for inhibiting beta-amyloid peptide release and/or its synthesis
作者:	Porter, W.J.; Eid, C.N.; Audia, J.E.; Britton, T.C.; Latimer, L.H.; Droste, J.J.; Scott, W.L.; Wu, J.; Tung, J.S.; Thorsett, E.D.; John, V.; Huffman, G.W.; (Athena Neurosciences, Inc.; Eli Lilly and Company)
来源:	JP 2001503782; WO 9822494

合成路线图解说明: The reaction of 3,5-difluorophenylacetic acid (I) with oxalyl chloride and DMF in dichloromethane gives the corresponding acyl chloride (II), which is condensed with L-alanine (III) by means of aqueous NaOH, yielding N-(3,5-difluorophenylacetyl)-L-alanine (IV). Finally, this compound is condensed with L-phenylglycine tert-butyl ester (V) by means of 2-ethoxy-1,2-dihydroquinoline-1-carboxylic acid ethyl ester (EEDQ) and NMM in THF.