The linear peptide-bound resin (VIII) was prepared by solid-phase synthesis on a Kaiser抯 oxime resin by sequential coupling-deprotection cycles with N-Boc-L-aminosuberic acid omega-benzyl ester (I), N-Boc-D-proline (III), N-Boc-L-isoleucine (V) and N-Boc-4-O-methyl-D-tyrosine (VII) to afford the peptide resins (II), (III), (IV) and (V), respectively. Cleavage of resin (VIII) with concomitant cyclization provided the cyclic tetrapeptide (IX). After hydrogenolysis of the side-chain benzyl ester, the resulting carboxylic acid was coupled to hydroxylamine in the presence of BOP and HOBt to obtain the title hydroxamic acid.