-药物合成数据库

【药物名称】

化学结构式(Chemical Structure):

参考文献No.	714395
标题:	Orally active analogues of the dopaminergic prodrug 6-(N,N-di-n-propylamino)-3,4,5,6,7,8-hexahydro- 2H-naphthalen-1-one: Synthesis and pharmacological activity
作者:	Venhuis, B.J.; Dijkstra, D.; Wustrow, D.J.; Meltzer, L.T.; Wise, L.D.; Johnson, S.J.; Heffner, T.G.; Wikstr鰉, H.V.
来源:	J Med Chem 2003,46(4),584

合成路线图解说明: Condensation of 1,2,3,4,5,6,7,8-octahydronaphthalene-1,6-dione (I) with N-ethyl propylamine (II) affords dienaminone (III). This is then reduced to the target compound employing NaBH3CN in the presence of AcOH.