【药物名称】DV-182
化学结构式(Chemical Structure):
参考文献No.47291
标题:Cyclic amides and imides having selective antagonist activity at alpha-1D adrenergic receptor
作者:Testa, R.; Leonardi, A.; Motta, G.; Barlocco, D. (Recordati Industria Chimica e Farmaceutica SpA)
来源:WO 0105765
合成路线图解说明:

Mitsunobu coupling of 3,3-tetramethyleneglutarimide (I) with 1-chloro-2-propanol (II) afforded the N-(2-chloro-1-methylethyl) glutarimide (III). This was then condensed with N-(2,5-dichlorophenyl)piperazine (IV) in the presence of Et3N at 180 C to furnish the title compound.

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