【药物名称】
化学结构式(Chemical Structure):
参考文献No.39776
标题:Inhibition of p38 kinase activity using aryl and heteroaryl substd. heterocyclic ureas
作者:Redman, A.; Smith, R.A.; Khire, U.; Wood, J.E.; Dumas, J.; Sibley, R.; Lowinger, T.B.; Scott, W.J.; Johnson, J.; Riedl, B.; Hatoum-Mokdad, H. (Bayer AG)
来源:WO 9932110
合成路线图解说明:

Aminopyrazole (III) was prepared by condensation of keto nitrile (I) with 3-nitrophenylhydrazine (II) in ethanolic HOAc. Subsequent reaction of (III) with 2,3-dichlorophenyl isocyanate (IV) in hot toluene produced the urea derivative (V). The nitro group of (V) was finally reduced to the title aniline by means of iron and acetic acid.

参考文献No.589791
标题:Synthesis and SAR of p38 kinase inhibitors from the urea class
作者:Dumas, J.; Bobko, M.; Bhargava, A.; et al.
来源:220th ACS Natl Meet (Aug 20 2000, Washington DC) 2000,Abst MEDI 148
合成路线图解说明:

Aminopyrazole (III) was prepared by condensation of keto nitrile (I) with 3-nitrophenylhydrazine (II) in ethanolic HOAc. Subsequent reaction of (III) with 2,3-dichlorophenyl isocyanate (IV) in hot toluene produced the urea derivative (V). The nitro group of (V) was finally reduced to the title aniline by means of iron and acetic acid.

参考文献No.589792
标题:Pharmacological characterization of pyrazolyl urea p38 kinase inhibitors
作者:Ranges, G.E.; Bortolon, E.; Chau, T.; et al.
来源:220th ACS Natl Meet (Aug 20 2000, Washington DC) 2000,Abst MEDI 149
合成路线图解说明:

Aminopyrazole (III) was prepared by condensation of keto nitrile (I) with 3-nitrophenylhydrazine (II) in ethanolic HOAc. Subsequent reaction of (III) with 2,3-dichlorophenyl isocyanate (IV) in hot toluene produced the urea derivative (V). The nitro group of (V) was finally reduced to the title aniline by means of iron and acetic acid.

参考文献No.593644
标题:1-Phenyl-5-pyrazolyl ureas: Potent and selective p38 kinase inhibitors
作者:Dumas, J.; Hatoum-Mokdad, H.; Sibley, R.; Riedl, B.; Scott, W.J.; Monahan, M.K.; Lowinger, T.B.; Brennan, C.; Natero, R.; Turner, T.; Johnson, J.S.; Schoenleber, R.; Bhargava, A.; Wilhelm, S.M.; Housley, T.J.; Ranges, G.E.; Shrikhande, A.
来源:Bioorg Med Chem Lett 2000,10(18),2051
合成路线图解说明:

Aminopyrazole (III) was prepared by condensation of keto nitrile (I) with 3-nitrophenylhydrazine (II) in ethanolic HOAc. Subsequent reaction of (III) with 2,3-dichlorophenyl isocyanate (IV) in hot toluene produced the urea derivative (V). The nitro group of (V) was finally reduced to the title aniline by means of iron and acetic acid.

Drug Information Express,Drug R&D,Chemical Database,Patent Search.
Copyright © 2006-2024 Drug Future. All rights reserved.Contact Us