【药物名称】
化学结构式(Chemical Structure):
参考文献No.44320
标题:Tricyclic inhibitors of poly(ADP-ribose) polymerases
作者:Thoresen, L.H.; Webber, S.E.; Tikhe, J.; Canan-Koch, S.S. (Agouron Pharmaceuticals, Inc.; Cancer Research Campaign Technology Ltd.)
来源:EP 1140936; WO 0042040
合成路线图解说明:

Condensation of methyl indole-4-carboxylate (I) with 2-nitroethyl acetate (II) produced the 3-nitroethyl indole (III). After reduction of the nitro group to amine (IV) using Zn and HCl, cyclization under basic conditions gave rise to lactam (V). Electrophilic bromination of (V) employing pyridinium tribromide furnished (VI). Finally, Suzuki coupling of bromide (VI) with 4-fluorobenzeneboronic acid (VII) yielded the title compound.

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