【药物名称】
化学结构式(Chemical Structure):
参考文献No.589267
标题:A new class of potential chloroquine-resistance reversal agents for plasmodia: Syntheses and biological evaluation of 1-(3'-diethylaminopropyl)-3-(substituted phenylmethylene)pyrrolidines
作者:Batra, S.; Srivastava, P.; Roy, K.; Pandey, V.C.; Bhaduri, A.P.
来源:J Med Chem 2000,43(18),3428
合成路线图解说明:

Condensation of 4-methoxybenzaldehyde (I) with gamma-butyrolactone (II) by means of NaOMe yields furanone derivative (III), which is then reduced in ether with LiAlH4 to afford diol (IV). Mesylation of (IV) by means of MsCl and Et3N in benzene provides dimesylate (V), which is finally condensed with amine (VI) with simultaneous cyclization in refluxing benzene.

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