Neomycin B-arginine conjugate, Neomycin B-hexaarginine conjugate, NeoR6, NeoR-药物合成数据库

【药物名称】Neomycin B-arginine conjugate, Neomycin B-hexaarginine conjugate, NeoR6, NeoR

化学结构式(Chemical Structure):

参考文献No.	44135
标题:	Anti-(retro)viral conjugates of saccharides and acetamidino or guanidino cpds.
作者:	Lapidot, A.; Litovchick, A.; Evdokimov, A. (Yeda Research & Development Co. Ltd.)
来源:	WO 0039139

合成路线图解说明: Acylation of neomycin B (I) with N-alpha-carbobenzoxy-N-omega-nitro-L-arginine (II) by means of EDC affords the protected neomycin B hexa-amide (III). Removal of the N-carbobenzoxy and N-nitro protecting groups of (III) is then achieved by catalytic hydrogenation over Pd/C, to furnish the title compound.

参考文献No.	685877
标题:	Neomycin B-arginine conjugate, a novel HIV-1 Tat antagonist: synthesis and anti-HIV activities
作者:	Litovchick, A.; Lapidot, A.; Eisenstein, M.; Kalinkovich, A.; Borkow, G.
来源:	Biochemistry 2001,40(51),15612

合成路线图解说明: Acylation of neomycin B (I) with N-alpha-carbobenzoxy-N-omega-nitro-L-arginine (II) by means of EDC affords the protected neomycin B hexa-amide (III). Removal of the N-carbobenzoxy and N-nitro protecting groups of (III) is then achieved by catalytic hydrogenation over Pd/C, to furnish the title compound.