-药物合成数据库

【药物名称】

化学结构式(Chemical Structure):

参考文献No.	43794
标题:	Novel thiolesters and uses thereof
作者:	Song, Y.; Turpin, J.A.; Huang, M.; Inman, J.K.; Walqvist, A.; Appella, E.; Maynard, A.; Rice, W.G.; Covell, D.G. (US Department of Health & Human Services)
来源:	WO 9965871

合成路线图解说明: Condensation of 2,2?dithiodibenzoyl chloride (I) with sulfacetamide (II) in pyridine afforded diamide (III). Reductive celavage of the disulfide bond of (III) by means of tris(2-carboxyethyl)phosphine produced the corresponding thiol (IV), which was subsequently acylated with 5-bromovaleryl chloride (V) yielding thioester (VI). Finally, displacement of the bromide with pyridine furnished the title pyridinium salt.

参考文献No.	582571
标题:	Synthesis and biological properties of novel pyridinioalkanoyl thiolesters (PATE) as anti-HIV-1 agents that target the viral nucleocapsid protein zinc fingers
作者:	Turpin, J.A.; Song, Y.; Inman, J.K.; Huang, M.; Wallqvist, A.; Maynard, A.; Covell, D.G.; Rice, W.G.; Appella, E.
来源:	J Med Chem 1999,42(1),67

合成路线图解说明: Condensation of 2,2?dithiodibenzoyl chloride (I) with sulfacetamide (II) in pyridine afforded diamide (III). Reductive celavage of the disulfide bond of (III) by means of tris(2-carboxyethyl)phosphine produced the corresponding thiol (IV), which was subsequently acylated with 5-bromovaleryl chloride (V) yielding thioester (VI). Finally, displacement of the bromide with pyridine furnished the title pyridinium salt.