【药物名称】SLV-310
化学结构式(Chemical Structure):
参考文献No.43142
标题:3-Tetrahydropyridin-4-yl indoles for treatment of psychotic disorders
作者:Kruse, C.G.; Tulp, M.T.M.; Van Hes, R.; Visser, G.M.; Van der Heijden, J.A.M.; Van Vliet, B.; Tipker, J. (Duphar International Research BV)
来源:EP 1121356; JP 2002527515; US 6391896; WO 0023441
合成路线图解说明:

Condensation of 5-fluoroindole (I) with 4-piperidone hydrate (II) under alkaline conditions leads to 5-fluoro-3-(1,2,3,6-tetrahydropyridin-4-yl)indole (III) (1,2). Subsequent alkylation of (III) with N-(4-bromobutyl)phthalimide (IV) furnishes the title compound (1-3).

参考文献No.62298
标题:Method of treating psychotic disorders
作者:Kruse, C.G.; Van Hes, R.; Long, S.K.; Van der Heijden, J.A.M. (Solvay Pharmaceuticals BV)
来源:WO 0069424
合成路线图解说明:

Condensation of 5-fluoroindole (I) with 4-piperidone hydrate (II) under alkaline conditions leads to 5-fluoro-3-(1,2,3,6-tetrahydropyridin-4-yl)indole (III) (1,2). Subsequent alkylation of (III) with N-(4-bromobutyl)phthalimide (IV) furnishes the title compound (1-3).

参考文献No.716175
标题:SLV310, a novel, potential antipsychotic, combining potent dopamine D2 receptor antagonism with serotonin reuptake inhibition
作者:Van Hes, R.; Smid, P.; Stroomer, C.N.J.; Tipker, K.; Tulp, M.T.M.; Van der Heyden, J.A.M.; McCreary, A.C.; Hesselink, M.B.; Kruse, C.G.
来源:Bioorg Med Chem Lett 2003,13(3),405
合成路线图解说明:

Condensation of 5-fluoroindole (I) with 4-piperidone hydrate (II) under alkaline conditions leads to 5-fluoro-3-(1,2,3,6-tetrahydropyridin-4-yl)indole (III) (1,2). Subsequent alkylation of (III) with N-(4-bromobutyl)phthalimide (IV) furnishes the title compound (1-3).

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