beta-L-IV-OddU-药物合成数据库

【药物名称】beta-L-IV-OddU

化学结构式(Chemical Structure):

参考文献No.	585749
标题:	Structure-activity relationships of (E)-5-(2-bromovinyl)uracil and related pyrimidine nucleosides as antiviral agents for herpes viruses
作者:	Choi, Y.; Li, L.; Grill, S.; Gullen, E.; Lee, C.S.; Gumina, G.; Tsujii, E.; Cheng, Y.-C.; Chu, C.K.
来源:	J Med Chem 2000,43(13),2538

合成路线图解说明: The condensation of the chiral dioxolane (I) with 5(E)-(2-bromovinyl)uracil (II) by means of Tbdms-OTf and lutidine gives the silylated nucleoside (II), which is purified by chromatography. Finally, this compound is deprotected by means of TBAF in acetonitrile. (1,2)

合成路线图解说明: The condensation of the chiral dioxolane (I) with 5(E)-(2-chlorovinyl)uracil (II) by means of Tbdms-OTf and lutidine gives the silylated nucleoside (II) that is purified by chromatography. Finally, this compound is deprotected by means of TBAF in acetonitrile.

合成路线图解说明: The condensation of the chiral dioxolane (I) with 5(E)-(2-iodovinyl)uracil (II) by means of Tbdms-OTf and lutidine gives the silylated nucleoside (II), which is purified by chromatography. Finally, this compound is deprotected by means of TBAF in acetonitrile.