【药物名称】beta-L-CV-OddU
化学结构式(Chemical Structure):
参考文献No.585749
标题:Structure-activity relationships of (E)-5-(2-bromovinyl)uracil and related pyrimidine nucleosides as antiviral agents for herpes viruses
作者:Choi, Y.; Li, L.; Grill, S.; Gullen, E.; Lee, C.S.; Gumina, G.; Tsujii, E.; Cheng, Y.-C.; Chu, C.K.
来源:J Med Chem 2000,43(13),2538
合成路线图解说明:

The condensation of the chiral dioxolane (I) with 5(E)-(2-bromovinyl)uracil (II) by means of Tbdms-OTf and lutidine gives the silylated nucleoside (II), which is purified by chromatography. Finally, this compound is deprotected by means of TBAF in acetonitrile. (1,2)

合成路线图解说明:

The condensation of the chiral dioxolane (I) with 5(E)-(2-chlorovinyl)uracil (II) by means of Tbdms-OTf and lutidine gives the silylated nucleoside (II) that is purified by chromatography. Finally, this compound is deprotected by means of TBAF in acetonitrile.

合成路线图解说明:

The condensation of the chiral dioxolane (I) with 5(E)-(2-iodovinyl)uracil (II) by means of Tbdms-OTf and lutidine gives the silylated nucleoside (II), which is purified by chromatography. Finally, this compound is deprotected by means of TBAF in acetonitrile.

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