DY-9804-药物合成数据库

【药物名称】DY-9804

化学结构式(Chemical Structure):

参考文献No.	22342
标题:	Diazabicycloalkene derivs.
作者:	Mimura, T.; Kubo, H. (Daiichi Pharmaceutical Co., Ltd.)
来源:	EP 0571822; JP 1994025233; US 5418232

合成路线图解说明: Condensation of 1,2-cyclo-propanedicarboxylic anhydride (I) with chlorobenzylhydrazine derivative (II) in EtOH (1) or acetonitrile affords derivative (III), which then reacts with epoxy-benzopyrancarbonitrile derivative (IV) in the presence of pyridine in EtOH to yield a mixture of two diastereomers (Va-b), from which the desired product is chromatographically separated.

参考文献No.	575034
标题:	Novel potassium channel opener prodrugs with a slow onset and prolonged duration of action
作者:	Horino, H.; Mimura, T.; Kobayashi, S.; Ohta, M.; Kubo, H.; Ito, K.; Tsumura, M.; Kitagawa, M.
来源:	Chem Pharm Bull 2000,48(4),490

合成路线图解说明: Condensation of 1,2-cyclo-propanedicarboxylic anhydride (I) with chlorobenzylhydrazine derivative (II) in EtOH (1) or acetonitrile affords derivative (III), which then reacts with epoxy-benzopyrancarbonitrile derivative (IV) in the presence of pyridine in EtOH to yield a mixture of two diastereomers (Va-b), from which the desired product is chromatographically separated.