【药物名称】
化学结构式(Chemical Structure):
参考文献No.575028
标题:Effect of the linking position of a side chain in bis (quinolymethyl)ethylenediamine as a DNA binding agent
作者:Mikata, Y.; Onchi, Y.; Kishigami, M.; Yano, S.
来源:Chem Pharm Bull 2000,48(4),477
合成路线图解说明:

Benzylic bromination of 2-methylquinoline (I) by means of N-bromosuccinimide afforded 2-(bromomethyl)quinoline (II). Dimerization of (II) using ethylenediamine gave the corresponding bis(quinolylmethyl)ethylenediamine, which was finally converted to the tetrahydrochloride salt.

合成路线图解说明:

Benzylic bromination of 8-methylquinoline (I) by means of N-bromosuccinimide afforded 8-(bromomethyl)quinoline (II). Dimerization of (II) using ethylenediamine gave the corresponding bis(quinolylmethyl)ethylenediamine, which was finally converted to the tetrahydrochloride salt.

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