【药物名称】FDPCICM
化学结构式(Chemical Structure):
参考文献No.573257
标题:New steroidal anti-inflammatory antedrugs: methyl 21-desoxy-21-chloro-11beta,17alpha-dihydroxy-3,20-dioxo-1,4-pregnadiene-16alpha-carboxylate, methyl 21-desoxy-21-chloro-11beta-hydroxy-3,20-dioxo-1,4-pregnadiene-16alpha-carboxylate, and their 9alpha-fluor
作者:Ko, D.H.; Heiman, A.S.; Chen, M.; Lee, H.J.
来源:Steroids 2000,65(4),210
合成路线图解说明:

The known 9alpha-fluoroprednisolone-16alpha-carboxylate derivative (I) was reacted with methanesulfonyl chloride and triethylamine to give the primary mesylate (II). Displacement of the mesylate group of (II) by LiCl in hot DMF produced the title chloro ketone.

Drug Information Express,Drug R&D,Chemical Database,Patent Search.
Copyright © 2006-2024 Drug Future. All rights reserved.Contact Us